Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 10/20 | 0.49 |
| ▸ | APP | P05067 | 6/20 | 0.49 |
| ▸ | SNCA | P37840 | 4/20 | 0.49 |
| ▸ | USP18 | Q9UMW8 | 2/20 | 0.47 |
| ▸ | UCHL5 | Q9Y5K5 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011121 | 0.84 | METAP1 (0.58) | METAP1MAPTHSP90AA1ALDH1A1KMT2A | |
| SCHEMBL2442647 | 0.78 | HPGD (0.50) | MAPTAPPALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL3093347 | 0.74 | ALDH1A1 (0.59) | METAP1MAPTAPPSNCAUSP18 | |
| SCHEMBL12865958 | 0.74 | METAP1 (0.55) | METAP1MAPTAPPSNCAUSP18 | |
| SCHEMBL7005593 | 0.73 | MAPT (0.63) | METAP1MAPTLMNA | |
| SCHEMBL29506223 | 0.73 | MAPT (0.56) | METAP1MAPTAPPSNCAUSP18 | |
| SCHEMBL7005334 | 0.73 | ALDH1A1 (0.58) | METAP1MAPTAPPSNCAALDH1A1 | |
| SCHEMBL11274474 | 0.72 | MAPT (0.64) | METAP1MAPTAPPSNCAUSP18 | |
| SCHEMBL17175833 | 0.72 | MAPT (0.58) | METAP1MAPTAPPSNCAUSP18 | |
| SCHEMBL28647928 | 0.71 | MAPT (0.63) | METAP1MAPTAPPSNCAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1103554-B9 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-12-17 | — | — | EP | disclosed |
| US-6548515-B1 | Use as anticancer agents | LES LABORATORIES SERVIER (FR) | 2003-04-15 | — | — | US | disclosed |
| EP-1103554-B1 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-03-12 | — | — | EP | disclosed |
| EP-1103554-A1 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-05-30 | — | — | EP | disclosed |