Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27891327 | 0.79 | NPC1 (0.34) | POLBNPC1RAB9AAPAF1NSD2 | |
| SCHEMBL1800270 | 0.73 | HSD17B10 (0.41) | POLBNPC1RAB9AAPAF1NSD2 | |
| SCHEMBL18631516 | 0.72 | ALDH1A1 (0.42) | POLBNPC1RAB9AAPAF1NSD2 | |
| SCHEMBL9797161 | 0.70 | HSD17B10 (0.38) | POLBNPC1RAB9AAPAF1NSD2 | |
| SCHEMBL12270203 | 0.69 | TOP1 (0.41) | POLBNPC1RAB9AAPAF1NSD2 | |
| SCHEMBL28648344 | 0.68 | ALDH1A1 (0.39) | POLBNPC1RAB9AAPAF1NSD2 | |
| SCHEMBL7018509 | 0.68 | ALDH1A1 (0.40) | POLBNPC1RAB9AAPAF1NSD2 | |
| SCHEMBL7014993 | 0.68 | CFTR (0.38) | POLBNPC1RAB9AAPAF1NSD2 | |
| SCHEMBL3087314 | 0.67 | ALDH1A1 (0.51) | POLBNPC1RAB9AAPAF1NSD2 | |
| SCHEMBL28036703 | 0.67 | MEN1 (0.39) | POLBNPC1RAB9AHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349861-A1 | THIENO(3,2-d)PYRIMIDINES AND FURANO(3,2-d)PYRIMIDINES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055524-A1 | THIENO(3,2-d)PYRIMIDINES AND FURANO(3,2-d)PYRIMIDINES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-07-18 | — | — | WO | disclosed |