Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800270 | 0.73 | HSD17B10 (0.41) | ALDH1A1HSD17B10MAPTKDM4EMEN1 | |
| SCHEMBL18631516 | 0.72 | ALDH1A1 (0.42) | ALDH1A1HSD17B10MAPTKDM4EMEN1 | |
| SCHEMBL9797161 | 0.70 | HSD17B10 (0.38) | ALDH1A1HSD17B10MAPTKDM4EMEN1 | |
| SCHEMBL4083662 | 0.69 | BCAT2 (0.43) | ALDH1A1ALOX15TSHRL3MBTL1 | |
| SCHEMBL12270203 | 0.69 | TOP1 (0.41) | ALDH1A1HSD17B10MAPTKDM4EMEN1 | |
| SCHEMBL16401835 | 0.68 | PIK3R1 (0.56) | CFTRALDH1A1ALOX15TSHRCYP1A2 | |
| SCHEMBL7007247 | 0.68 | POLB (0.39) | ALDH1A1HSD17B10MAPTKDM4EMEN1 | |
| SCHEMBL7018509 | 0.68 | ALDH1A1 (0.40) | ALDH1A1HSD17B10MAPTKDM4EMEN1 | |
| SCHEMBL3087314 | 0.67 | ALDH1A1 (0.51) | ALDH1A1HSD17B10MAPTKDM4EMEN1 | |
| SCHEMBL27891327 | 0.66 | NPC1 (0.34) | ALDH1A1HSD17B10MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349861-A1 | THIENO(3,2-d)PYRIMIDINES AND FURANO(3,2-d)PYRIMIDINES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055524-A1 | THIENO(3,2-d)PYRIMIDINES AND FURANO(3,2-d)PYRIMIDINES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-07-18 | — | — | WO | disclosed |