Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.58 |
| ▸ | HTR1B | P28222 | 10/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR1F | P30939 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995996 | 0.86 | SLC6A4 (0.59) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7006135 | 0.79 | HTR1B (0.62) | HTR1DHTR1BHTR1ANOS1 | |
| SCHEMBL7011235 | 0.79 | SLC6A4 (0.84) | HTR1BSLC6A4HTR1A | |
| SCHEMBL6642008 | 0.79 | HTR1D (0.63) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6996942 | 0.79 | SLC6A4 (0.61) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8381443 | 0.79 | CYP1A2 (0.63) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7006549 | 0.78 | HTR1D (0.49) | HTR1DHTR1BCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7007317 | 0.78 | MPO (0.54) | HTR1DHTR1BSLC6A4 | |
| SCHEMBL7002497 | 0.76 | SLC6A4 (0.61) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23010847 | 0.75 | HTR1D (0.72) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098896-B1 | 5-BICYCLOINDOLE COMPOUNDS | NPS ALLELIX CORP (CA) | 2003-06-25 | — | — | EP | claimed |
| EP-1098896-B1 | 5-BICYCLOINDOLE COMPOUNDS | NPS ALLELIX CORP (CA) | 2003-06-25 | — | — | EP | disclosed |