Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014691 | 0.80 | CYP11B1 (0.42) | MEN1KMT2ATSHRALOX15CYP11B1 | |
| SCHEMBL27958208 | 0.72 | CYP11B1 (0.54) | MEN1KMT2ATSHRALOX15CYP11B1 | |
| SCHEMBL6660795 | 0.72 | MEN1 (1.00) | MEN1KMT2ATSHRALOX15CYP11B1 | |
| SCHEMBL4865755 | 0.71 | MEN1 (0.71) | MEN1KMT2ATSHRALOX15CYP11B1 | |
| Water SCHEMBL6337291 | 0.70 | MEN1 (0.96) | MEN1KMT2ATSHRALOX15CYP11B1 | |
| SCHEMBL7644186 | 0.68 | CYP3A4 (0.48) | MEN1KMT2ATSHRALOX15CYP11B1 | |
| SCHEMBL6471796 | 0.68 | ADH5 (0.63) | MEN1KMT2ATSHRALOX15CYP3A4 | |
| SCHEMBL27590600 | 0.67 | CYP3A4 (0.47) | MEN1KMT2ATSHRALOX15CYP11B1 | |
| SCHEMBL14699584 | 0.67 | MEN1 (0.50) | MEN1KMT2ATSHRALOX15CYP11B1 | |
| SCHEMBL28061806 | 0.67 | CYP3A4 (0.50) | MEN1KMT2ATSHRALOX15CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065209-B1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-05-02 | — | — | EP | disclosed |
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |
| EP-1065209-A1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-03 | — | — | EP | disclosed |