Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007434 | 0.80 | MEN1 (0.56) | CYP11B1CYP11B2NOTUMLMNAMAPT | |
| SCHEMBL8445207 | 0.72 | HDAC6 (0.41) | CYP11B1CYP11B2HDAC6NOTUMLMNA | |
| SCHEMBL13989268 | 0.70 | HTT (0.51) | CYP11B1CYP11B2MAPTHTTKMT2A | |
| SCHEMBL12841363 | 0.67 | GABRG2 (0.68) | GABRG2GABRB3GABRA5GABRA3FAAH | |
| SCHEMBL3764275 | 0.67 | HTR1A (0.54) | FAAHCYP1A2MAPK1ALDH1A1HSD17B10 | |
| SCHEMBL7915311 | 0.65 | HSD17B1 (0.61) | HDAC6CYP2C9CYP2C19ALDH1A1DYRK1A | |
| SCHEMBL27708181 | 0.64 | HDAC6 (0.41) | CYP11B1CYP11B2HDAC6NOTUMLMNA | |
| SCHEMBL379478 | 0.64 | HDAC6 (0.44) | CYP11B1CYP11B2HDAC6NOTUMLMNA | |
| SCHEMBL5695918 | 0.63 | ALDH1A1 (0.43) | CYP11B1CYP11B2HDAC6NOTUMLMNA | |
| SCHEMBL883778 | 0.63 | ALDH1A1 (0.44) | CYP11B1CYP11B2HDAC6NOTUMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065209-B1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-05-02 | — | — | EP | disclosed |
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |
| EP-1065209-A1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-03 | — | — | EP | disclosed |