SCHEMBL7007771

SCHEMBL7007771

COc1ccc(C)c(-c2nccc3ccccc23)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 5/20 0.46
MAOA P21397 1/20 0.45
CYP11B1 P15538 4/20 0.44
CYP11B2 P19099 4/20 0.44
CYP2A6 P11509 2/20 0.44
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
TUBA3C P0DPH7 1/20 0.44
TUBA1B P68363 1/20 0.44
TUBA4A P68366 1/20 0.44
TUBB4B P68371 1/20 0.44
TUBB3 Q13509 1/20 0.44
TUBB2A Q13885 1/20 0.44
TUBB8 Q3ZCM7 1/20 0.44
TUBA3E Q6PEY2 1/20 0.44
TUBA1A Q71U36 1/20 0.44
TUBA1C Q9BQE3 1/20 0.44
TUBB6 Q9BUF5 1/20 0.44
TUBB2B Q9BVA1 1/20 0.44
TUBB1 Q9H4B7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12320582 0.89 CRHR1 (0.50) SCN9AMAOACYP11B1CYP11B2CYP2A6
SCHEMBL7003794 0.86 SCN9A (0.45) SCN9ACYP11B1CYP11B2CYP2A6HTR2C
SCHEMBL7003795 0.86 SCN9A (0.57) SCN9ACYP2A6CYP1A2CYP3A4CYP2C19
SCHEMBL7005329 0.85 SCN9A (0.42) SCN9AMAOACYP2A6CYP1A2CYP3A4
SCHEMBL7005201 0.83 SCN9A (0.43) SCN9AMAOACYP2A6CYP1A2CYP3A4
SCHEMBL7004461 0.83 MAOA (0.44) SCN9AMAOACYP2A6LMNA
SCHEMBL18753201 0.82 CYP2A6 (0.49) SCN9AMAOACYP2A6BCHECYP1A2
SCHEMBL1445543 0.81 LMNA (0.45) MAOACYP11B1CYP11B2TUBB4ATUBB
SCHEMBL7004339 0.81 MAOA (0.46) SCN9AMAOACYP2A6CYP2D6L3MBTL1
SCHEMBL15668159 0.79 CYP2A6 (0.46) CYP2A6BCHECYP1A2PLAUCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2802594-B1 METAL COMPLEXES WITH DIBENZO[F,H]QUINOXALINES UDC IRELAND LTD (IE) 2017-04-19 EP disclosed
WO-2012064499-A1 PHOSPHORESCENT MATERIALS UNIVERSAL DISPLAY CORPORATION (US) 2012-05-18 WO disclosed