Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8217289 | 0.99 | CHRNA7 (0.52) | CHRNA7HTR1ADRD1PDE7APDE7B | |
| Hydrochloric Acid SCHEMBL7505359 | 0.99 | CHRNA7 (0.52) | CHRNA7HTR1ADRD1PDE7APDE7B | |
| SCHEMBL7010627 | 0.94 | PDE7A (0.47) | CHRNA7HTR1ADRD1PDE7APDE7B | |
| Iodide SCHEMBL7011688 | 0.93 | PDE7A (0.46) | CHRNA7HTR1ADRD1PDE7APDE7B | |
| SCHEMBL8216078 | 0.80 | MEN1 (0.60) | — | |
| Hydrochloric Acid SCHEMBL8213780 | 0.79 | MEN1 (0.59) | — | |
| SCHEMBL7011686 | 0.78 | SLC18A3 (0.44) | HTR1A | |
| Nitric Acid SCHEMBL7839376 | 0.76 | CHRNA7 (0.77) | CHRNA7 | |
| SCHEMBL7013563 | 0.76 | ALDH1A1 (0.40) | CHRNA7 | |
| SCHEMBL9495772 | 0.76 | SLC18A3 (0.46) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| US-6140322-A | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 2000-10-31 | — | — | US | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |
| WO-2000008023-A1 | CONDENSED TRICYCLIC PIPERIDINES HAVING ANTI-CONVULSANT ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-17 | — | — | WO | disclosed |
| WO-2000008022-A1 | UREA DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2000-02-17 | — | — | WO | disclosed |
| US-5929085-A | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 1999-07-27 | — | — | US | disclosed |