Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015158 | 0.76 | CHRNA7 (0.43) | CHRNA7 | |
| SCHEMBL7008003 | 0.76 | CHRNA7 (0.54) | CHRNA7 | |
| Iodide SCHEMBL8217289 | 0.75 | CHRNA7 (0.52) | CHRNA7 | |
| Hydrochloric Acid SCHEMBL7505359 | 0.75 | CHRNA7 (0.52) | CHRNA7 | |
| SCHEMBL7010627 | 0.73 | PDE7A (0.47) | CHRNA7 | |
| Iodide SCHEMBL7011688 | 0.72 | PDE7A (0.46) | CHRNA7 | |
| SCHEMBL16082789 | 0.72 | ALDH1A1 (0.37) | ALDH1A1MAPK1HTTMAPTLMNA | |
| SCHEMBL31378803 | 0.71 | MAPT (0.36) | ALDH1A1MAPK1HTTMAPT | |
| SCHEMBL31403689 | 0.69 | OPRK1 (0.37) | ALDH1A1MAPK1HTTMAPT | |
| SCHEMBL31403692 | 0.69 | OPRK1 (0.37) | ALDH1A1MAPK1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |