SCHEMBL7008205

SCHEMBL7008205

CCOC(=O)c1c(Cl)c(CC)c(C)[nH]c1=O

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.54
CYP2C19 P33261 2/20 0.54
ALDH1A1 P00352 4/20 0.49
KDM4E B2RXH2 1/20 0.48
LMNA P02545 3/20 0.46
MAPT P10636 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
HPGD P15428 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.44
CYP2C9 P11712 1/20 0.44
POLB P06746 2/20 0.43
NPC1 O15118 1/20 0.43
GAA P10253 1/20 0.43
MAPK1 P28482 1/20 0.43
PDE4D Q08499 1/20 0.42
PDE3B Q13370 1/20 0.41
PDE3A Q14432 1/20 0.41
CSF1R P07333 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26664855 0.84 HPGD (0.51) CYP1A2CYP2C19ALDH1A1KDM4ELMNA
SCHEMBL5188877 0.84 CYP1A2 (0.60) CYP1A2CYP2C19ALDH1A1KDM4ELMNA
SCHEMBL3401547 0.79 KDM4E (0.53) ALDH1A1KDM4ELMNAMAPTL3MBTL1
SCHEMBL16972721 0.78 TP53 (0.56) CYP1A2CYP2C19ALDH1A1KDM4ELMNA
SCHEMBL11645963 0.76 SMN1; SMN2 (0.61) CYP1A2CYP2C19ALDH1A1KDM4ELMNA
SCHEMBL26664851 0.76 ALOX5 (0.48) CYP1A2CYP2C19ALDH1A1KDM4ELMNA
SCHEMBL31686289 0.76 ALOX5 (0.48) CYP1A2CYP2C19ALDH1A1KDM4ELMNA
SCHEMBL6023616 0.75 LMNA (0.52) CYP1A2CYP2C19ALDH1A1KDM4ELMNA
SCHEMBL5187530 0.74 CYP1A2 (0.46) CYP1A2CYP2C19ALDH1A1KDM4ELMNA
SCHEMBL26601966 0.72 LMNA (0.56) CYP1A2CYP2C19ALDH1A1KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0843663-B9 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES CENTRE NAT RECH SCIENT (FR) 2003-10-29 EP disclosed
EP-0843663-B1 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES CENTRE NAT RECH SCIENT (FR) 2003-04-09 EP disclosed
US-6015820-A VIRICIDES; AIDS TREATMENT CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2000-01-18 US disclosed
WO-1997005113-A1 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1997-02-13 WO disclosed