SCHEMBL7008802

SCHEMBL7008802

Cc1ccc(S(=O)(=O)OC(=O)c2cn(-c3cc(N)c(F)cc3F)c3c(Cl)c(N4CC(N)C4)c(F)cc3c2=O)cc1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.51
CYP2C9 P11712 1/20 0.51
ALDH1A1 P00352 1/20 0.41
POLB P06746 1/20 0.41
CHRM2 P08172 1/20 0.41
CHRM1 P11229 1/20 0.41
OPRM1 P35372 1/20 0.41
OPRD1 P41143 1/20 0.41
TOP2A P11388 14/20 0.40
TOP1 P11387 4/20 0.40
TOP2B Q02880 10/20 0.39
KDM4E B2RXH2 1/20 0.35
HPGD P15428 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7011758 0.88 CYP3A4 (0.55) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7008800 0.88 CYP3A4 (0.58) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7007346 0.83 LMNA (0.49) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7011751 0.83 CYP3A4 (0.65) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7004804 0.82 CYP3A4 (0.71) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL8564353 0.79 ALDH1A1 (0.68) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL7013849 0.78 CYP3A4 (0.66) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7010547 0.77 CYP3A4 (0.64) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7004810 0.77 CYP3A4 (0.68) CYP3A4CYP2C9ALDH1A1POLBCHRM2
SCHEMBL7003705 0.77 CYP3A4 (0.68) CYP3A4CYP2C9ALDH1A1POLBCHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787720-B1 PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KK (JP) 2003-07-16 EP disclosed
US-5910498-A NOVEL COMPOUNDS HAVING REDUCED CYTOTOXICITY, PHOTOTOXICITY; TREATING BACTERIAL AND VIRAL INFECTIONS WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1999-06-08 US disclosed
EP-0787720-A1 NOVEL PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1997-08-06 EP disclosed