SCHEMBL7008847

SCHEMBL7008847

CN1CC=C(c2cn([Si](C)(C)C(C)(C)C)c3ccc(Br)cc23)CC1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 2/20 0.51
HTR6 P50406 9/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12127432 0.84 SLC6A4 (0.53) SLC6A4HTR6
SCHEMBL12127428 0.77 SLC6A4 (0.50) SLC6A4HTR6
SCHEMBL6997441 0.77 HTR6 (0.36) HTR6
SCHEMBL6997445 0.77 HTR6 (0.36) HTR6
SCHEMBL7006768 0.73 HTR6 (0.40) HTR6
SCHEMBL3340516 0.72 HTR6 (0.78) SLC6A4HTR6
SCHEMBL7488659 0.71 HTR6 (0.77) SLC6A4HTR6
SCHEMBL4142457 0.71 MAPT (0.34)
SCHEMBL7482977 0.69 HTR6 (0.77) SLC6A4HTR6
SCHEMBL4729029 0.68 HTR6 (0.78) SLC6A4HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1098896-B1 5-BICYCLOINDOLE COMPOUNDS NPS ALLELIX CORP (CA) 2003-06-25 EP disclosed
EP-1098896-A1 5-BICYCLOINDOLE COMPOUNDS NPS Allelix Corp. (CA) 2001-05-16 EP disclosed
WO-2000004019-A1 5-BICYCLOINDOLE COMPOUNDS ALLELIX BIOPHARMACEUTICALS INC. (CA) 2000-01-27 WO disclosed