Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816834 | 0.84 | L3MBTL1 (0.55) | ALDH1A1ATML3MBTL1CYP1A2GAA | |
| SCHEMBL9042897 | 0.84 | ALDH1A1 (0.62) | ALDH1A1ATML3MBTL1CYP1A2SMN1; SMN2 | |
| SCHEMBL2558718 | 0.81 | ATM (0.68) | ALDH1A1ATML3MBTL1CYP1A2SMN1; SMN2 | |
| SCHEMBL27571544 | 0.80 | CA1 (0.52) | ALDH1A1L3MBTL1SMN1; SMN2FGFR1HTT | |
| SCHEMBL7007417 | 0.80 | TDP1 (0.52) | ALDH1A1L3MBTL1SMN1; SMN2FGFR1HTT | |
| SCHEMBL7822354 | 0.79 | CA12 (0.49) | ALDH1A1ATML3MBTL1CYP1A2GAA | |
| SCHEMBL27523948 | 0.78 | FGFR1 (0.50) | ALDH1A1L3MBTL1SMN1; SMN2FGFR1HTT | |
| SCHEMBL5786109 | 0.78 | CYP1A2 (0.54) | ALDH1A1ATML3MBTL1CYP1A2GAA | |
| SCHEMBL28432330 | 0.77 | ALDH1A1 (0.51) | ALDH1A1GAACA12CA1CA2 | |
| SCHEMBL6377479 | 0.76 | FGFR1 (0.55) | ALDH1A1L3MBTL1FGFR1HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |