Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 10/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6615858 | 0.94 | BCHE (0.44) | PARP14BCHEHPGDSCHRM2HTR1A | |
| Fumaric Acid SCHEMBL6615862 | 0.94 | BCHE (0.44) | PARP14BCHEHPGDSCHRM2HTR1A | |
| SCHEMBL6616529 | 0.86 | PARP14 (0.46) | PARP14BCHEHPGDSCHRM2HTR1A | |
| SCHEMBL8147561 | 0.85 | PARP14 (0.49) | PARP14BCHEHPGDSCHRM2HTR1A | |
| Fumaric Acid SCHEMBL6619772 | 0.85 | BCHE (0.47) | PARP14BCHEHPGDSCHRM2HTR1A | |
| Fumaric Acid SCHEMBL6619768 | 0.85 | BCHE (0.47) | PARP14BCHEHPGDSCHRM2HTR1A | |
| SCHEMBL7009681 | 0.84 | ALDH1A1 (0.46) | CHRM2ADRA2ASLC6A2ADRA1ADRD3 | |
| Hydrochloric Acid SCHEMBL6617880 | 0.83 | ALOX5 (0.46) | CHRM2ADRA2ASLC6A2ADRA1ADRD3 | |
| SCHEMBL6622174 | 0.83 | BCHE (0.45) | PARP14BCHEHPGDSCHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL6618531 | 0.81 | BCHE (0.51) | PARP14BCHEHPGDSCHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123936-B1 | FUSED PYRIDAZINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1123936-A1 | FUSED PYRIDAZINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-08-16 | — | — | EP | disclosed |