Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.44 |
| ▸ | HRH2 | P25021 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6617880 | 0.99 | ALOX5 (0.46) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL8136555 | 0.90 | ALDH1A1 (0.43) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL6619396 | 0.90 | ALDH1A1 (0.43) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL6622834 | 0.90 | ALDH1A1 (0.43) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL7219268 | 0.89 | P2RX7 (0.48) | ALOX5P2RX7 | |
| Hydrochloric Acid SCHEMBL6618120 | 0.88 | P2RX7 (0.48) | ALOX5P2RX7 | |
| SCHEMBL6620940 | 0.85 | ALDH1A1 (0.52) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL7009347 | 0.84 | PARP14 (0.45) | LMNAMAPK1HRH1HRH2HTR2A | |
| Hydrochloric Acid SCHEMBL6619934 | 0.83 | ALDH1A1 (0.47) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL6618725 | 0.81 | P2RX7 (0.42) | ALDH1A1ALOX5DRD3DRD2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123936-B1 | FUSED PYRIDAZINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1123936-A1 | FUSED PYRIDAZINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-08-16 | — | — | EP | disclosed |