Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009071 | 0.86 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL6290801 | 0.83 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL7007985 | 0.79 | KMT2A (0.52) | MAPK14KDM4ERIPK3 | |
| SCHEMBL6294480 | 0.78 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL7009324 | 0.78 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL6294049 | 0.77 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL6294505 | 0.77 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL6294026 | 0.75 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL7008536 | 0.66 | RIPK3 (0.45) | MAPK14RIPK3 | |
| SCHEMBL7012237 | 0.66 | RIPK3 (0.45) | MAPK14RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252163-B1 | 4-PYRIDYL-AND 2,4-PYRIMIDINYL-SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE IN PHARMACY | MERCKLE GMBH (DE) | 2003-09-24 | — | — | EP | disclosed |
| EP-1252163-A2 | 4-PYRIDYL-AND 2,4-PYRIMIDINYL-SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE IN PHARMACY | MERCKLE GMBH (DE) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057042-A2 | 4-PYRIDYL-AND 2,4-PYRIMIDINYL-SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE IN PHARMACY | MERCKLE GMBH (DE) | 2001-08-09 | — | — | WO | disclosed |