Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.36 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009987 | 1.00 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1CYP11B1CYP11B2GAA | |
| SCHEMBL1508462 | 0.82 | AKR1C3 (0.47) | ALDH1A1L3MBTL1CYP11B1CYP11B2GAA | |
| SCHEMBL1508463 | 0.82 | AKR1C3 (0.47) | ALDH1A1L3MBTL1CYP11B1CYP11B2GAA | |
| SCHEMBL16673102 | 0.82 | MEN1 (0.53) | ALDH1A1L3MBTL1CYP11B1CYP11B2GAA | |
| SCHEMBL4661456 | 0.82 | KDM4E (0.50) | ALDH1A1GAALMNAKMT2AMEN1 | |
| SCHEMBL4661459 | 0.82 | KDM4E (0.50) | ALDH1A1GAALMNAKMT2AMEN1 | |
| SCHEMBL9681007 | 0.78 | MEN1 (0.42) | ALDH1A1LMNAKMT2AMEN1BCHE | |
| SCHEMBL9680999 | 0.78 | MEN1 (0.42) | ALDH1A1LMNAKMT2AMEN1BCHE | |
| SCHEMBL11004166 | 0.75 | MAPT (0.46) | ALDH1A1L3MBTL1GAAPTGES2LMNA | |
| SCHEMBL11004161 | 0.75 | MAPT (0.46) | ALDH1A1L3MBTL1GAAPTGES2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |