Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 3/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680999 | 1.00 | MEN1 (0.42) | MEN1KMT2ALMNATHRBBLM | |
| SCHEMBL31065882 | 0.85 | ERN1 (0.39) | ERN1TLR2TLR1TLR6TRIM24 | |
| SCHEMBL9681561 | 0.80 | MEN1 (0.38) | MEN1KMT2ALMNATHRBBLM | |
| SCHEMBL9681557 | 0.80 | MEN1 (0.38) | MEN1KMT2ALMNATHRBBLM | |
| SCHEMBL28915528 | 0.78 | AKR1C3 (0.58) | MEN1KMT2ATDP1ALDH1A1TSHR | |
| SCHEMBL20853874 | 0.78 | AKR1C3 (0.58) | MEN1KMT2ATDP1ALDH1A1TSHR | |
| SCHEMBL7009992 | 0.78 | ALDH1A1 (0.39) | MEN1KMT2ALMNAALDH1A1BCHE | |
| SCHEMBL7009987 | 0.78 | ALDH1A1 (0.39) | MEN1KMT2ALMNAALDH1A1BCHE | |
| SCHEMBL9680987 | 0.77 | KMT2A (0.50) | MEN1KMT2ALMNATHRBBLM | |
| SCHEMBL9680982 | 0.77 | KMT2A (0.50) | MEN1KMT2ALMNATHRBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162345-A | Dihydropyridinedicarboxylate Derivatives | GLAXO, S.P.A. (IT) | 1992-11-10 | — | — | US | disclosed |
| US-5091395-A | Hypotensive agents | GLAXO S.P.A. (IT) | 1992-02-25 | — | — | US | disclosed |
| EP-0226271-B1 | 1,4-DIHYDROPYRIDINE COMPOUNDS AND THEIR PREPARATION AND PHARMACEUTICAL FORMULATION | GLAXO S.p.A. (IT) | 1990-11-22 | — | — | EP | disclosed |
| EP-0226271-A1 | 1,4-Dihydropyridine compounds and their preparation and pharmaceutical formulation | GLAXO S.p.A. (IT) | 1987-06-24 | — | — | EP | disclosed |