SCHEMBL7010042

SCHEMBL7010042

COc1ccc(C(OCCS(=O)(=O)CCO)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC6A11 P48066 4/20 0.46
SLC6A1 P30531 2/20 0.46
KMT2A Q03164 2/20 0.45
MEN1 O00255 1/20 0.41
TP53 P04637 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
SLC6A12 P48065 1/20 0.41
SLC6A13 Q9NSD5 1/20 0.41
KIF11 P52732 5/20 0.40
HSD11B1 P28845 1/20 0.40
HTT P42858 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27013149 0.88 SLC6A11 (0.44) SLC6A11SLC6A1KMT2AMEN1TP53
SCHEMBL8655117 0.88 SLC6A11 (0.44) SLC6A11SLC6A1KMT2AMEN1TP53
SCHEMBL8388886 0.85 SLC6A11 (0.44) SLC6A11SLC6A1KMT2AMEN1TP53
SCHEMBL8659005 0.85 SLC6A11 (0.45) SLC6A11SLC6A1KMT2AMEN1TP53
SCHEMBL9305514 0.85 SLC6A11 (0.43) SLC6A11SLC6A1KMT2AMEN1TP53
SCHEMBL9305860 0.83 SLC6A11 (0.41) SLC6A11SLC6A1KMT2AMEN1TP53
SCHEMBL2490410 0.83 SLC6A11 (0.50) SLC6A11SLC6A1KMT2AMEN1TP53
SCHEMBL992028 0.83 SLC6A11 (0.50) SLC6A11SLC6A1KMT2AMEN1TP53
SCHEMBL21449650 0.81 SLC6A11 (0.40) SLC6A11SLC6A1KMT2AMEN1TP53
SCHEMBL21449652 0.81 SLC6A11 (0.40) SLC6A11SLC6A1KMT2AMEN1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240254149-A1 Chemical Phosphorylation Reagents, Preparation, and Their Uses OLIX US, INC. 2024-08-01 US disclosed
EP-4341270-A1 CHEMICAL PHOSPHORYLATION REAGENTS, PREPARATION, AND THEIR USES Olix US, Inc. (US) 2024-03-27 EP disclosed
CN-117580848-A Chemical phosphorylating reagent, preparation and use thereof 奥利克斯美国公司 2024-02-20 CN disclosed
WO-2022246196-A1 CHEMICAL PHOSPHORYLATION REAGENTS, PREPARATION, AND THEIR USES OLIX US, INC. (US) 2022-11-24 WO disclosed
EP-0816368-B1 Chemical phoshorylation of oligonucleotides and reactants used therefor GLEN RES CORP (US) 2003-01-08 EP disclosed
EP-0804414-A4 COMPLEMENTARY DNA AND TOXINS SLOAN KETTERING INST CANCER (US) 2000-04-12 EP disclosed
US-5959090-A FORMING PHOSPHORAMIDITE COMPOUNDS FROM PHOSPHORYLATION GLEN RESEARCH CORPORATION (US) 1999-09-28 US disclosed
US-5807837-A ADMINISTERING TO TREAT HIV INFECTIONS TO INHIBIT THE REPLICATION OF FOREIGN NUCLEIC ACIDS IN A NORMAL CELL SANKYO COMPANY, LIMITED (JP) 1998-09-15 US disclosed
EP-0816368-A1 Chemical phoshorylation of oligonucleotides and reactants used therefor Glen Research Corporation (US) 1998-01-07 EP disclosed
EP-0804414-A1 COMPLEMENTARY DNA AND TOXINS Sloan-Kettering Institute For Cancer Research (US) 1997-11-05 EP disclosed
US-5674856-A TREATMENT AND PROPHYLAXIS OF VIRAL INFECTIONS, INCLUDING AIDS AND TUMORS SANKYO COMPANY, LIMITED (JP) 1997-10-07 US disclosed
US-5652350-A Complementary DNA and toxins SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1997-07-29 US disclosed
EP-0611075-B1 Modified oligodeoxyribonucleotides, their preparation and their therapeutic use SANKYO CO (JP) 1996-12-18 EP disclosed
WO-1995031434-A1 COMPLEMENTARY DNA AND TOXINS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1995-11-23 WO disclosed
EP-0611075-A1 Modified oligodeoxyribonucleotides, their preparation and their therapeutic use SANKYO COMPANY LIMITED (JP) 1994-08-17 EP disclosed
US-5332845-A In DNA synthesis CHIRON CORPORATION (US) 1994-07-26 US disclosed
US-5256549-A Biosynthesis using blocked monomers; followed by enzymatic hydrolysis CHIRON CORPORATION (US) 1993-10-26 US disclosed
US-5252760-A Method of using colored phosphorylating reagents CHIRON CORPORATION (US) 1993-10-12 US disclosed
EP-0304215-A2 Phosphorylating reagents and method of using the same CHIRON CORPORATION (US) 1989-02-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240254149-A1 Chemical Phosphorylation Reagents, Preparation, and Their Uses PTMS, PPP4C, CHAMP1 SLC6A11 4570/4885SLC6A1 4606/4885KMT2A 2135/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.