Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532147 | 0.94 | POLB (0.65) | POLBHPGDALOX15GRM5KMT2A | |
| Hydrochloric Acid SCHEMBL2550272 | 0.92 | POLB (0.63) | POLBHPGDALOX15GRM5KMT2A | |
| SCHEMBL14980308 | 0.89 | POLB (0.72) | POLBHPGDALOX15GRM5KMT2A | |
| SCHEMBL29253633 | 0.87 | HPGD (0.61) | POLBHPGDALOX15GRM5KMT2A | |
| SCHEMBL7010056 | 0.86 | L3MBTL1 (0.60) | POLBHPGDALOX15GRM5KMT2A | |
| SCHEMBL29950978 | 0.85 | HPGD (0.57) | POLBHPGDALOX15KMT2AMEN1 | |
| SCHEMBL10724841 | 0.82 | POLB (0.81) | POLBHPGDALOX15GRM5KMT2A | |
| SCHEMBL9133746 | 0.80 | ALDH1A1 (0.64) | POLBHPGDKMT2AMEN1LMNA | |
| SCHEMBL204078 | 0.79 | HPGD (0.70) | HPGDKMT2AMEN1LMNATSHR | |
| SCHEMBL950365 | 0.79 | HPGD (0.64) | POLBHPGDKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296981-A2 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001087882-A2 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-22 | — | — | WO | disclosed |