Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010051 | 0.86 | POLB (0.59) | POLBCYP2C9GRM5KMT2ATSHR | |
| SCHEMBL6411599 | 0.86 | L3MBTL1 (0.69) | L3MBTL1POLBMAPTCYP2C9GRM5 | |
| SCHEMBL532147 | 0.80 | POLB (0.65) | L3MBTL1POLBCYP2C9GRM5KMT2A | |
| SCHEMBL29954605 | 0.80 | HTT (0.58) | L3MBTL1KMT2ATSHRALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL2550272 | 0.79 | POLB (0.63) | L3MBTL1POLBCYP2C9GRM5KMT2A | |
| SCHEMBL11887769 | 0.76 | L3MBTL1 (0.81) | L3MBTL1POLBMAPTGRM5KMT2A | |
| SCHEMBL14980308 | 0.75 | POLB (0.72) | L3MBTL1POLBCYP2C9GRM5KMT2A | |
| SCHEMBL10722273 | 0.75 | L3MBTL1 (0.74) | L3MBTL1POLBMAPTGRM5KMT2A | |
| SCHEMBL29253633 | 0.74 | HPGD (0.61) | L3MBTL1POLBGRM5KMT2ATSHR | |
| SCHEMBL29956909 | 0.74 | HTT (0.64) | L3MBTL1POLBKMT2ATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296981-A2 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001087882-A2 | SUBSTITUTED PYRROLOPYRIDINONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-22 | — | — | WO | disclosed |