Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27687262 | 0.84 | LRRK2 (0.51) | LRRK2MAP2K1RAF1FLT1KDR | |
| SCHEMBL7014960 | 0.81 | LRRK2 (0.50) | LRRK2MAP2K1RAF1EGFRFLT1 | |
| SCHEMBL3156282 | 0.76 | LRRK2 (0.50) | LRRK2MAP2K1RAF1EGFRKDR | |
| SCHEMBL5707689 | 0.74 | ESR1 (0.51) | ALDH1A1HPGDNPSR1KDM4EMAPT | |
| SCHEMBL31054165 | 0.73 | LRRK2 (0.45) | LRRK2MAP2K1RAF1EGFRFLT1 | |
| SCHEMBL3881412 | 0.73 | ADORA1 (0.41) | LRRK2MAP2K1EGFRFLT1KDR | |
| SCHEMBL15431217 | 0.69 | TSHR (0.52) | ALDH1A1HPGDNPSR1KDM4EMAPT | |
| SCHEMBL7010219 | 0.69 | ALDH1A1 (0.50) | KDRCDK1ADORA1ALDH1A1HPGD | |
| SCHEMBL12176924 | 0.68 | TSHR (0.50) | ALDH1A1HPGDNPSR1KDM4EMAPT | |
| SCHEMBL1164857 | 0.67 | LRRK2 (0.54) | LRRK2MAP2K1RAF1EGFRADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |