Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27687262 | 0.87 | LRRK2 (0.51) | LRRK2ALDH1A1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL7010214 | 0.81 | LRRK2 (0.44) | LRRK2ALDH1A1NPSR1HTTMAPT | |
| SCHEMBL28261068 | 0.78 | ALDH1A1 (0.54) | ALDH1A1NPSR1HTTSMN1; SMN2MAPT | |
| SCHEMBL4515509 | 0.77 | GRM5 (0.45) | LRRK2GRM5EGFRERBB2 | |
| SCHEMBL3151307 | 0.77 | LRRK2 (0.58) | LRRK2ALDH1A1CDK1KDRPLK4 | |
| SCHEMBL31054165 | 0.77 | LRRK2 (0.45) | LRRK2ALDH1A1NPSR1CDK1KDR | |
| SCHEMBL1103260 | 0.75 | HTT (0.48) | ALDH1A1NPSR1HTTSMN1; SMN2MAPT | |
| SCHEMBL1103411 | 0.73 | ALDH1A1 (0.52) | ALDH1A1NPSR1HTTSMN1; SMN2MAPT | |
| SCHEMBL12156904 | 0.71 | LRRK2 (0.72) | LRRK2ALDH1A1MAP2K1RAF1CYP1A2 | |
| SCHEMBL601228 | 0.71 | TDP1 (0.57) | ALDH1A1NPSR1HTTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |