Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 17/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374462 | 0.93 | HTR7 (0.59) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4374847 | 0.87 | HTR7 (0.42) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7013050 | 0.84 | HTR7 (0.53) | HTR7ADRA1DADRA1AADRA1B | |
| SCHEMBL7011497 | 0.82 | ALDH1A1 (0.46) | HTR7ADRA1DADRA1AADRA1BPLK1 | |
| SCHEMBL7014743 | 0.81 | HTR7 (0.53) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7098780 | 0.81 | PLK1 (0.42) | HTR7ADRA1DADRA1AADRA1BPLK1 | |
| SCHEMBL4374758 | 0.81 | HTR7 (0.54) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4379084 | 0.81 | HTR7 (0.54) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7009242 | 0.79 | HTR7 (0.46) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4375475 | 0.77 | KMT2A (0.51) | HTR7HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-A4 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2003-08-06 | — | — | EP | disclosed |
| EP-1280781-A1 | 5-HT 7 RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001085701-A1 | 5-HT7 RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-15 | — | — | WO | disclosed |