Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | LDHB | P07195 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 5/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | KRAS | P01116 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013050 | 0.84 | HTR7 (0.53) | HTR7ADRA1DADRA1AADRA1BHDAC3 | |
| SCHEMBL7011497 | 0.84 | ALDH1A1 (0.46) | PLK1HTR7ADRA1DADRA1AADRA1B | |
| SCHEMBL4375361 | 0.82 | SOS1 (0.46) | LDHALDHBSOS1DHFREGFR | |
| SCHEMBL7014743 | 0.82 | HTR7 (0.53) | HTR7ADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL7010237 | 0.81 | HTR7 (0.57) | PLK1HTR7ADRA1DADRA1AADRA1B | |
| SCHEMBL11373574 | 0.81 | DHFR (0.58) | DHFRMEN1KMT2A | |
| SCHEMBL4374462 | 0.80 | HTR7 (0.59) | HTR7ADRA1DADRA1AADRA1B | |
| SCHEMBL7009242 | 0.80 | HTR7 (0.46) | HTR7ADRA1DADRA1AADRA1BEGFR | |
| SCHEMBL7011283 | 0.77 | HTR7 (0.43) | LDHALDHBHTR7ADRA1DADRA1A | |
| SCHEMBL4375475 | 0.77 | KMT2A (0.51) | HTR7MEN1KMT2ATAAR1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-A4 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2003-08-06 | — | — | EP | claimed |
| EP-1280781-A1 | 5-HT 7 RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2003-02-05 | — | — | EP | claimed |
| WO-2001085701-A1 | 5-HT7 RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-15 | — | — | WO | claimed |