SCHEMBL7010585

SCHEMBL7010585

O=[N+]([O-])c1cc(O)cnc1Br

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.42
HSP90AB1 P08238 1/20 0.42
ERN1 O75460 1/20 0.39
GPR35 Q9HC97 7/20 0.38
ALDH1A1 P00352 4/20 0.37
KDM4E B2RXH2 3/20 0.37
MAPT P10636 3/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
CTSB P07858 1/20 0.37
GAA P10253 1/20 0.37
IDO1 P14902 1/20 0.37
TDO2 P48775 1/20 0.37
HPGD P15428 2/20 0.36
MAPK1 P28482 2/20 0.36
TP53 P04637 1/20 0.36
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
SNCA P37840 1/20 0.36
TTR P02766 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29600703 0.80 ERN1 (0.41) ERN1ALDH1A1MAPTMEN1KMT2A
SCHEMBL202290 0.80 ERN1 (0.41) ERN1ALDH1A1MAPTMEN1KMT2A
SCHEMBL2082959 0.78 ALDH1A1 (0.50) GPR35ALDH1A1KDM4EMAPTMEN1
SCHEMBL1762953 0.77 TDP1 (0.41) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL126682 0.77 TSHR (0.41) GPR35ALDH1A1MAPK1TSHRL3MBTL1
SCHEMBL126405 0.77 SMN1; SMN2 (0.54) GPR35ALDH1A1KDM4EMAPTGAA
SCHEMBL1721986 0.77 ALDH1A1 (0.35) ERN1GPR35ALDH1A1MAPTMEN1
SCHEMBL30230648 0.77 SMN1; SMN2 (0.54) GPR35ALDH1A1KDM4EMAPTGAA
SCHEMBL7463751 0.77 GPR35 (0.47) HSP90AA1HSP90AB1GPR35ALDH1A1KDM4E
SCHEMBL1607842 0.77 CASP6 (0.51) ALDH1A1TSHRTDP1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1359908-A1 QUINOLINES AND NITROGENATED DERIVATIVES THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM PLC (GB) 2003-11-12 EP disclosed
WO-2002056882-A1 QUINOLINES AND NITROGENATED DERIVAIVE THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM P.L.C. (GB) 2002-07-25 WO disclosed