Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 13/20 | 0.34 |
| ▸ | DHFR | P00374 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009670 | 0.79 | GRIN2D (0.41) | PDE3BPDE3ASMN1; SMN2HSD17B10TYMS | |
| SCHEMBL7007080 | 0.77 | MAPT (0.39) | PDE3BPDE3ASMN1; SMN2HSD17B10HTT | |
| SCHEMBL7010610 | 0.77 | ALDH1A1 (0.46) | PDE3BPDE3AMAPT | |
| SCHEMBL7013173 | 0.75 | TYMS (0.32) | TYMSDHFRPKMHTTMAPT | |
| SCHEMBL5701705 | 0.74 | KDM4E (0.39) | PDE3BPDE3ASMN1; SMN2HSD17B10DHFR | |
| SCHEMBL7012912 | 0.72 | SMN1; SMN2 (0.38) | PDE3BPDE3ASMN1; SMN2HSD17B10HTT | |
| SCHEMBL8086596 | 0.70 | KDM4E (0.44) | SMN1; SMN2HSD17B10MAPT | |
| SCHEMBL7007761 | 0.70 | MCL1 (0.33) | TYMSDHFR | |
| SCHEMBL9846258 | 0.69 | TYMP (0.39) | PDE3BPDE3ASMN1; SMN2HSD17B10HTT | |
| SCHEMBL6086721 | 0.69 | TYMP (0.37) | PDE3BPDE3ASMN1; SMN2HSD17B10DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843663-B9 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-10-29 | — | — | EP | claimed |
| EP-0843663-B1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-04-09 | — | — | EP | claimed |
| US-6015820-A | VIRICIDES; AIDS TREATMENT | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2000-01-18 | — | — | US | claimed |
| EP-0843663-B9 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-10-29 | — | — | EP | disclosed |
| EP-0843663-B1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NAT RECH SCIENT (FR) | 2003-04-09 | — | — | EP | disclosed |
| US-6015820-A | VIRICIDES; AIDS TREATMENT | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2000-01-18 | — | — | US | disclosed |
| WO-1997005113-A1 | 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 1997-02-13 | — | — | WO | disclosed |