Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7202591 | 0.75 | CYP1A2 (0.41) | PDE3BPDE3AALDH1A1HSD17B10KDM4E | |
| SCHEMBL5701705 | 0.71 | KDM4E (0.39) | PDE3BPDE3AALDH1A1HSD17B10KDM4E | |
| SCHEMBL19261715 | 0.71 | PDE3B (0.42) | TYMPPDE3BPDE3AALDH1A1HSD17B10 | |
| SCHEMBL3794931 | 0.71 | KDM4E (0.64) | ALDH1A1HSD17B10KDM4EHPGDALOX15 | |
| SCHEMBL9846189 | 0.69 | GRIN2D (0.45) | PDE3BPDE3AALDH1A1HSD17B10KDM4E | |
| SCHEMBL6060630 | 0.69 | HSD17B10 (0.47) | PDE3BPDE3AALDH1A1HSD17B10KDM4E | |
| SCHEMBL7010909 | 0.69 | PDE3B (0.35) | PDE3BPDE3AHSD17B10SMN1; SMN2HTT | |
| SCHEMBL28132135 | 0.69 | NOS3 (0.36) | KDM4E | |
| SCHEMBL3027104 | 0.69 | NOS3 (0.36) | KDM4E | |
| SCHEMBL7202599 | 0.68 | CYP1A2 (0.42) | PDE3BPDE3AALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |