Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.39 |
| ▸ | NOS2 | P35228 | 3/20 | 0.39 |
| ▸ | NCF1 | P14598 | 3/20 | 0.39 |
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | NCK1 | P16333 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7015916 | 0.98 | BACE1 (0.38) | BACE1NOS2NCF1PLAUNCK1 | |
| SCHEMBL1097841 | 0.75 | PIK3CB (0.47) | BACE1NOS2NCF1PLAUNCK1 | |
| SCHEMBL31036108 | 0.75 | PIK3CB (0.47) | BACE1NOS2NCF1PLAUNCK1 | |
| SCHEMBL21874281 | 0.73 | RAB9A (0.38) | BACE1NOS2NCF1PLAUMEN1 | |
| SCHEMBL26596983 | 0.71 | BACE1 (0.35) | BACE1NOS2NCF1PLAUNCK1 | |
| SCHEMBL26632791 | 0.71 | BACE1 (0.35) | BACE1NOS2NCF1PLAUNCK1 | |
| SCHEMBL12032567 | 0.68 | HTR6 (0.41) | BACE1NOS2NCF1PLAUNCK1 | |
| SCHEMBL26612204 | 0.66 | DHFR (0.36) | BACE1NOS2NCF1PLAUNCK1 | |
| SCHEMBL4542820 | 0.66 | TLR8 (0.45) | KMT2A | |
| SCHEMBL21964302 | 0.66 | PIK3CA (0.43) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0916669-B1 | Processes and intermediates for the preparation of Pyrrolo(3,2-b)pyridine | LILLY CO ELI (US) | 2003-04-09 | — | — | EP | claimed |
| US-6150525-A | Pyrrolo [3,2-b]pyridine processes and intermediates | ELI LILLY AND COMPANY (US) | 2000-11-21 | — | — | US | claimed |
| WO-1999025708-A1 | PYRROLO[3,2-b]PYRIDINE PROCESSES AND INTERMEDIATES | ELI LILLY AND COMPANY (US) | 1999-05-27 | — | — | WO | claimed |
| EP-0916669-A2 | Processes and intermediates for the preparation of Pyrrolo(3,2-b)pyridine | ELI LILLY AND COMPANY (US) | 1999-05-19 | — | — | EP | claimed |
| EP-0916669-B1 | Processes and intermediates for the preparation of Pyrrolo(3,2-b)pyridine | LILLY CO ELI (US) | 2003-04-09 | — | — | EP | disclosed |
| US-6150525-A | Pyrrolo [3,2-b]pyridine processes and intermediates | ELI LILLY AND COMPANY (US) | 2000-11-21 | — | — | US | disclosed |
| EP-0916669-A2 | Processes and intermediates for the preparation of Pyrrolo(3,2-b)pyridine | ELI LILLY AND COMPANY (US) | 1999-05-19 | — | — | EP | disclosed |