Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 9/20 | 0.43 |
| ▸ | APP | P05067 | 5/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 4/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019437 | 0.94 | PDE5A (0.49) | PDE5A | |
| SCHEMBL7014271 | 0.91 | APP (0.42) | CCR4PDE5AAPPHRH4PDE4A | |
| SCHEMBL7422776 | 0.91 | CCR4 (0.42) | CCR4PDE5AAPPHRH4PDE4A | |
| SCHEMBL8177126 | 0.90 | PDE4A (0.52) | CCR4PDE5AAPPHRH4PDE4A | |
| SCHEMBL7015416 | 0.90 | ACHE (0.41) | CCR4PDE5AAPPHRH4PDE4A | |
| SCHEMBL7020576 | 0.88 | PDE4A (0.44) | PDE5AHRH4PDE4APDE4BPDE4C | |
| SCHEMBL7016859 | 0.88 | ACHE (0.40) | CCR4PDE5AAPPACHEBCHE | |
| SCHEMBL7021443 | 0.88 | PDE5A (0.41) | CCR4PDE5AAPPPDE4APDE4B | |
| SCHEMBL7017050 | 0.88 | HRH4 (0.50) | HRH4 | |
| SCHEMBL7020325 | 0.87 | HRH4 (0.47) | PDE5AHRH4PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |