Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.40 |
| ▸ | APP | P05067 | 6/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 4/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | WHR1 | P49842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016530 | 0.93 | PDE5A (0.47) | PDE5A | |
| SCHEMBL7013933 | 0.92 | APP (0.39) | ACHEAPPBCHETP53CCR4 | |
| SCHEMBL8180973 | 0.91 | PDE4A (0.46) | ACHEAPPBCHETP53CCR4 | |
| SCHEMBL7015416 | 0.89 | ACHE (0.41) | ACHEAPPBCHETP53CCR4 | |
| SCHEMBL7014271 | 0.89 | APP (0.42) | ACHEAPPBCHETP53CCR4 | |
| SCHEMBL7012148 | 0.89 | CTNNB1 (0.48) | CTNNB1TCF7L2 | |
| SCHEMBL7011635 | 0.88 | CCR4 (0.44) | ACHEAPPBCHETP53CCR4 | |
| SCHEMBL7019976 | 0.88 | PDE5A (0.43) | CTNNB1TCF7L2PDE5A | |
| SCHEMBL7019018 | 0.88 | CTNNB1 (0.42) | CTNNB1TCF7L2PDE5A | |
| SCHEMBL8169893 | 0.87 | ALDH1A1 (0.47) | TP53CCR4CTNNB1TCF7L2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |