Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 14/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 13/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | TOP1 | P11387 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006461 | 0.92 | TOP2A (0.45) | TOP2ATOP2BTOP1KDM4EALDH1A1 | |
| SCHEMBL7012384 | 0.90 | TOP2A (0.42) | TOP2ATOP2BTOP1KDM4EALDH1A1 | |
| SCHEMBL7010345 | 0.88 | TOP2A (0.39) | TOP2ATOP2BTOP1KDM4EALDH1A1 | |
| SCHEMBL7011692 | 0.84 | LMNA (0.47) | TOP2ATOP2BCYP3A4CYP2C9KDM4E | |
| SCHEMBL7014477 | 0.83 | TOP2A (0.48) | TOP2ATOP2BCYP3A4CYP2C9KDM4E | |
| SCHEMBL7011787 | 0.82 | ALDH1A1 (0.40) | TOP2ATOP2BCYP2C9TOP1KDM4E | |
| SCHEMBL7010854 | 0.82 | EPHA2 (0.43) | TOP2ATOP2BCYP3A4CYP2C9TOP1 | |
| SCHEMBL7010843 | 0.81 | EPHA2 (0.37) | TOP2ATOP2BCYP3A4CYP2C9TOP1 | |
| SCHEMBL9048751 | 0.80 | TOP1 (0.45) | TOP2ATOP2BCYP3A4CYP2C9TOP1 | |
| SCHEMBL7007995 | 0.79 | TOP2A (0.60) | TOP2ATOP2BCYP2C9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775702-B1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO LTD (JP) | 2003-07-23 | — | — | EP | disclosed |
| US-5935952-A | ANTIBACTERIAL AGENT | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0775702-A1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-05-28 | — | — | EP | disclosed |