Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12448368 | 0.95 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTSMN1; SMN2HRH2 | |
| SCHEMBL22117865 | 0.88 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTSMN1; SMN2HRH2 | |
| SCHEMBL22118025 | 0.86 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTSMN1; SMN2HRH2 | |
| SCHEMBL7005111 | 0.83 | DRD3 (0.48) | ALDH1A1DRD3DRD2RXFP1 | |
| SCHEMBL18910916 | 0.83 | MAPT (0.52) | ALDH1A1LMNAMAPTSMN1; SMN2HRH2 | |
| SCHEMBL16570456 | 0.83 | HRH2 (0.64) | ALDH1A1LMNAMAPTHRH2HRH1 | |
| SCHEMBL21644472 | 0.82 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPT | |
| SCHEMBL25398475 | 0.82 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTSMN1; SMN2HRH2 | |
| SCHEMBL1929880 | 0.81 | LTA4H (0.57) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL15244045 | 0.81 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |