Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | GPR4 | P46093 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667304 | 0.95 | NSD2 (0.49) | DRD3NR1H2NSD2EHMT2CFTR | |
| SCHEMBL22118030 | 0.87 | HTR1B (0.52) | NR1H2RXFP1ALDH1A1EPHX2GPR4 | |
| SCHEMBL22118023 | 0.85 | RXFP1 (0.48) | NR1H2RXFP1ALDH1A1EPHX2GPR4 | |
| SCHEMBL7011905 | 0.83 | ALDH1A1 (0.53) | DRD3DRD2RXFP1ALDH1A1 | |
| SCHEMBL1669652 | 0.83 | GPR119 (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL18910793 | 0.82 | EPHX2 (0.48) | NR1H2NSD2EHMT2ALDH1A1EPHX2 | |
| SCHEMBL14453658 | 0.82 | DRD3 (0.54) | DRD3DRD2ALDH1A1EPHX2GPR4 | |
| SCHEMBL28343487 | 0.81 | AXL (0.51) | — | |
| SCHEMBL7003036 | 0.80 | RXFP1 (0.44) | DRD3DRD2RXFP1NSD2EHMT2 | |
| SCHEMBL18910796 | 0.80 | EPHX2 (0.47) | NR1H2RXFP1NSD2EHMT2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |