Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | IL2 | P60568 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7021808 | 0.85 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7016224 | 0.84 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7015704 | 0.81 | PDE4D (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7020167 | 0.77 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7019362 | 0.75 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7013469 | 0.70 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL15432258 | 0.69 | HPGD (0.49) | KDM4EIL2ALDH1A1IKBKETBK1 | |
| SCHEMBL7017434 | 0.69 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7406540 | 0.68 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DIL2 | |
| SCHEMBL7010243 | 0.68 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | claimed |