Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.39 |
| ▸ | POLQ | O75417 | 3/20 | 0.38 |
| ▸ | IL2 | P60568 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018885 | 0.78 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7019133 | 0.68 | — | — | |
| SCHEMBL7011973 | 0.68 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DIKBKE | |
| SCHEMBL7019315 | 0.67 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7021808 | 0.67 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DIKBKE | |
| SCHEMBL7406581 | 0.65 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPOLQ | |
| SCHEMBL4153508 | 0.64 | TSHR (0.49) | IL2 | |
| SCHEMBL27781445 | 0.64 | TYK2 (0.65) | — | |
| SCHEMBL21870351 | 0.63 | RAB9A (0.60) | — | |
| SCHEMBL15432258 | 0.63 | HPGD (0.49) | IKBKETBK1IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | Darwin Discovery Limited (GB) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064423-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LIMITED (GB) | 1999-12-16 | — | — | WO | disclosed |