Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.61 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 8/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | VDR | P11473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957360 | 0.90 | MMP13 (0.74) | MMP13TRPA1CCR2KMT2ASMN1; SMN2 | |
| SCHEMBL7106604 | 0.86 | MMP13 (0.60) | MMP13TRPA1P2RX3KMT2ASMN1; SMN2 | |
| SCHEMBL5957426 | 0.84 | TRPA1 (0.67) | MMP13TRPA1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5957483 | 0.81 | TRPA1 (0.53) | MMP13TRPA1KMT2AKDM4EMEN1 | |
| SCHEMBL5957565 | 0.80 | MMP13 (0.78) | MMP13TRPA1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5957708 | 0.77 | MMP13 (0.67) | MMP13TRPA1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5957461 | 0.76 | MMP13 (1.00) | MMP13TRPA1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5957700 | 0.76 | MMP13 (0.66) | MMP13TRPA1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL6235332 | 0.76 | TRPA1 (0.72) | TRPA1VDR | |
| SCHEMBL5957566 | 0.74 | MMP13 (0.57) | MMP13TRPA1CCR2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362054-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064599-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |