Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.60 |
| ▸ | TRPA1 | O75762 | 8/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957360 | 0.89 | MMP13 (0.74) | MMP13TRPA1KMT2AMEN1KDM4E | |
| SCHEMBL7012216 | 0.86 | MMP13 (0.61) | MMP13TRPA1KMT2AMEN1KDM4E | |
| SCHEMBL5957520 | 0.84 | TRPA1 (0.67) | MMP13TRPA1GSK3BMAPK1 | |
| SCHEMBL5957475 | 0.84 | MMP13 (0.88) | MMP13TRPA1KMT2AMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL5957471 | 0.83 | MMP13 (0.86) | MMP13TRPA1KMT2AMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL5957599 | 0.83 | TRPA1 (0.66) | MMP13TRPA1GSK3BMAPK1 | |
| Hydrochloric Acid SCHEMBL5957820 | 0.83 | TRPA1 (0.66) | MMP13TRPA1GSK3BMAPK1 | |
| SCHEMBL5957565 | 0.79 | MMP13 (0.78) | MMP13TRPA1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL5957708 | 0.76 | MMP13 (0.67) | MMP13TRPA1KMT2AMEN1KDM4E | |
| SCHEMBL5957700 | 0.75 | MMP13 (0.66) | MMP13TRPA1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362054-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064599-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |
| EP-1362054-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064599-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |