Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 9/20 | 0.32 |
| ▸ | SLC16A1 | P53985 | 8/20 | 0.32 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.32 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013353 | 0.89 | GABRB2 (0.38) | POLBTDP1L3MBTL1SLC16A3SLC16A1 | |
| SCHEMBL7014975 | 0.86 | NOTUM (0.31) | — | |
| SCHEMBL7011250 | 0.84 | GAA (0.39) | L3MBTL1BDKRB2 | |
| SCHEMBL7005740 | 0.83 | BDKRB2 (0.41) | POLBSLC16A3SLC16A1BDKRB2 | |
| SCHEMBL7006530 | 0.82 | BDKRB2 (0.32) | BDKRB2 | |
| SCHEMBL7007702 | 0.82 | LMNA (0.32) | — | |
| SCHEMBL7012849 | 0.81 | BDKRB2 (0.40) | POLBBDKRB2 | |
| SCHEMBL8722561 | 0.81 | BDKRB2 (0.36) | POLBBDKRB2 | |
| SCHEMBL7008463 | 0.80 | CYP1A2 (0.32) | — | |
| SCHEMBL7005681 | 0.80 | BDKRB2 (0.40) | POLBL3MBTL1BDKRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861243-B1 | HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-11-12 | — | — | EP | disclosed |
| US-6344462-B1 | Heterocyclic compounds as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-05 | — | — | US | disclosed |
| US-6100284-A | ANTIALLERGENS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-08 | — | — | US | disclosed |
| US-6008229-A | TREATING ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0861243-A1 | HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997011069-A1 | HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-27 | — | — | WO | disclosed |