Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 15/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.40 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.40 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ATP4A | P20648 | 1/20 | 0.39 |
| ▸ | ATP4B | P51164 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014374 | 0.89 | PLA2G1B (0.57) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL8615510 | 0.87 | PLA2G1B (0.50) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL7007210 | 0.84 | PLA2G1B (0.53) | PLA2G1BPLA2G2APLA2G2EPLA2G5PTGER1 | |
| SCHEMBL7013840 | 0.77 | PLA2G1B (0.47) | PLA2G1BPLA2G2APLA2G2EPLA2G5ATP4A | |
| SCHEMBL7013764 | 0.75 | PLA2G1B (0.58) | PLA2G1BPLA2G2APLA2G2EPLA2G5ALDH1A1 | |
| SCHEMBL7014263 | 0.72 | PLA2G1B (0.39) | PLA2G1BKDM4EALDH1A1 | |
| SCHEMBL7017215 | 0.72 | PLA2G1B (0.83) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL8318865 | 0.72 | PLA2G1B (0.48) | PLA2G1BPLA2G2APLA2G2EPLA2G5ALDH1A1 | |
| SCHEMBL8615512 | 0.72 | PLA2G1B (0.43) | PLA2G1BPLA2G2APLA2G2EPLA2G5PTGER1 | |
| SCHEMBL7013388 | 0.71 | PLA2G1B (0.48) | PLA2G1BPLA2G2AATP4AATP4BPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |