Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014122 | 0.87 | PLA2G1B (0.53) | PLA2G1BMAPK14 | |
| SCHEMBL8345231 | 0.82 | KDM4E (0.45) | PLA2G1BL3MBTL1GAAMAPK1ALDH1A1 | |
| SCHEMBL7011352 | 0.79 | FOLH1 (0.47) | PLA2G1BMAPK14L3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL5661211 | 0.76 | TBXAS1 (0.53) | CFDTBXAS1L3MBTL1NR1H4GAA | |
| SCHEMBL7011022 | 0.75 | KDM4E (0.44) | L3MBTL1GAAALDH1A1MAPTTDP1 | |
| SCHEMBL3952696 | 0.73 | RXRA (0.49) | PLA2G1BL3MBTL1MAPK1MAPTTDP1 | |
| SCHEMBL7012444 | 0.72 | PLA2G1B (0.46) | PLA2G1BALDH1A1KDM4E | |
| SCHEMBL9080973 | 0.72 | KMT2A (0.41) | GAAALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL13794527 | 0.70 | MAPT (0.45) | L3MBTL1GAAMAPK1ALDH1A1MAPT | |
| SCHEMBL7052623 | 0.70 | PPIA (0.53) | MAPK14L3MBTL1NR1H4MAPK1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |