Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 9/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.37 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.37 |
| ▸ | ATP4A | P20648 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013764 | 0.86 | PLA2G1B (0.58) | PLA2G1BRXRARXRBRXRGMCL1 | |
| SCHEMBL7007210 | 0.83 | PLA2G1B (0.53) | PLA2G1BRXRARXRBRXRGPTGER1 | |
| SCHEMBL8324753 | 0.79 | RXRA (0.42) | PLA2G1BRXRARXRBRXRGMCL1 | |
| SCHEMBL9080978 | 0.78 | PLA2G1B (0.57) | PLA2G1BATP4AATP4B | |
| SCHEMBL8615510 | 0.76 | PLA2G1B (0.50) | PLA2G1BPLA2G10PLA2G2APLA2G5PLA2G2E | |
| SCHEMBL8323100 | 0.75 | PLA2G1B (0.83) | PLA2G1BPLA2G10PLA2G2APLA2G5PLA2G2E | |
| SCHEMBL7014374 | 0.73 | PLA2G1B (0.57) | PLA2G1BPLA2G2APLA2G5PLA2G2E | |
| SCHEMBL7013840 | 0.73 | PLA2G1B (0.47) | PLA2G1BRXRARXRBRXRGMCL1 | |
| SCHEMBL7012444 | 0.72 | PLA2G1B (0.46) | PLA2G1BPTGER1ALDH1A1PLA2G2APLA2G5 | |
| SCHEMBL8615512 | 0.72 | PLA2G1B (0.43) | PLA2G1BRXRARXRBRXRGMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |