Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 3/20 | 0.34 |
| ▸ | ACACA | Q13085 | 3/20 | 0.34 |
| ▸ | PKLR | P30613 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017152 | 0.87 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL7015009 | 0.76 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL7015742 | 0.70 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DSCD5 | |
| SCHEMBL7011850 | 0.69 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL7022444 | 0.67 | CCNT1 (0.38) | — | |
| SCHEMBL7017255 | 0.67 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DSCD5 | |
| SCHEMBL25175297 | 0.66 | GAA (0.45) | SCD5ALDH1A1HSD17B10HPGD | |
| SCHEMBL7010146 | 0.66 | CCNT1 (0.36) | — | |
| SCHEMBL5740735 | 0.64 | HSD17B10 (0.45) | SCD5ALDH1A1HSD17B10HPGD | |
| SCHEMBL15941976 | 0.64 | OPRD1 (0.38) | SCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | disclosed |
| EP-1086106-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | Darwin Discovery Limited (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-6169090-B1 | FOR INHIBITION OF PHOSPHODIESTERASE IV | DARWIN DISCOVERY, LTD. (GB) | 2001-01-02 | — | — | US | disclosed |
| WO-1999064423-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LIMITED (GB) | 1999-12-16 | — | — | WO | disclosed |