Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | NAMPT | P43490 | 6/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015009 | 0.89 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| Tert-Butanol SCHEMBL7012645 | 0.87 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL7011850 | 0.82 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL7015742 | 0.81 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL7016954 | 0.74 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL7015027 | 0.72 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL23411531 | 0.72 | PIK3CA (0.42) | GPR119NAMPTOPRD1OPRK1 | |
| SCHEMBL5472913 | 0.71 | GPR119 (0.52) | GPR119CYP2C9JAK2JAK1OPRD1 | |
| SCHEMBL3258235 | 0.69 | OPRD1 (0.50) | PDE4APDE4BPDE4CPDE4DGPR119 | |
| SCHEMBL1513657 | 0.68 | TSHR (0.55) | GPR119OPRD1OPRK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | disclosed |
| EP-1086106-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | Darwin Discovery Limited (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-6169090-B1 | FOR INHIBITION OF PHOSPHODIESTERASE IV | DARWIN DISCOVERY, LTD. (GB) | 2001-01-02 | — | — | US | disclosed |
| WO-1999064423-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LIMITED (GB) | 1999-12-16 | — | — | WO | disclosed |