Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PARG | Q86W56 | 7/20 | 0.40 |
| ▸ | PDE5A | O76074 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014557 | 0.79 | PDE1A (0.42) | ALDH1A1LMNAPARGPDE5APDE3B | |
| SCHEMBL7008632 | 0.76 | BRD4 (0.41) | ALDH1A1LMNAPOLBPARGCYP3A4 | |
| SCHEMBL7014116 | 0.75 | PDE2A (0.42) | ALDH1A1LMNAPARGMEN1KMT2A | |
| SCHEMBL7008006 | 0.73 | PARG (0.43) | ALDH1A1LMNAPOLBPARGPDE5A | |
| SCHEMBL4803221 | 0.64 | ALDH1A1 (0.43) | ALDH1A1LMNAPOLBPARGPDE5A | |
| SCHEMBL6350931 | 0.64 | NOTUM (0.44) | ALDH1A1LMNAPOLBPARGPDE5A | |
| SCHEMBL5403546 | 0.64 | PDE5A (0.45) | ALDH1A1LMNAPOLBPARGPDE5A | |
| SCHEMBL7007286 | 0.64 | PDE1B (0.38) | ALDH1A1PARGPDE5APDE3BPDE3A | |
| SCHEMBL6254904 | 0.64 | MAPK8 (0.41) | ALDH1A1LMNAPARGADORA1 | |
| SCHEMBL5864669 | 0.62 | PDE1B (0.47) | LMNAPDE3BPDE3ASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| US-6300334-B1 | DRUGS FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| EP-1107973-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012514-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |