Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.42 |
| ▸ | PDE1A | P54750 | 3/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005435 | 0.85 | PDE1B (0.57) | PDE2APDE1APDE1BPDE1CPKM | |
| SCHEMBL7006914 | 0.81 | PDE2A (0.45) | PDE2APDE1APDE1BPDE1CPKM | |
| SCHEMBL7008632 | 0.80 | BRD4 (0.41) | PKMLMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL7012658 | 0.75 | ALDH1A1 (0.43) | PKMLMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7005962 | 0.72 | KMT2A (0.42) | PKMLMNAHTTTSHRSMN1; SMN2 | |
| SCHEMBL16404602 | 0.68 | HTT (0.62) | LMNAHTTNPSR1TSHRCYP11B1 | |
| SCHEMBL7005664 | 0.67 | PDE1A (0.43) | PDE2APDE1APDE1BPDE1CLMNA | |
| SCHEMBL7007034 | 0.67 | PDE1B (0.45) | PDE2APDE1APDE1BPDE1CLMNA | |
| SCHEMBL7008006 | 0.65 | PARG (0.43) | LMNAALDH1A1PARG | |
| SCHEMBL7008659 | 0.64 | SLC16A1 (0.57) | PDE2APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | claimed |