Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.45 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091107 | 0.92 | NPC1 (0.48) | NPC1GABRA2GABRB2ALDH1A1LMNA | |
| SCHEMBL19986908 | 0.88 | ALDH1A1 (0.49) | NPC1PIM1IRAK1CAMK2BCAMK2G | |
| SCHEMBL10587033 | 0.88 | GABRA2 (0.41) | NPC1GABRA2GABRB2ALDH1A1TSHR | |
| SCHEMBL3236130 | 0.85 | KMT2A (0.48) | NPC1ALDH1A1LMNAMAPTSTAT3 | |
| SCHEMBL7008116 | 0.85 | KDM4E (0.46) | NPC1GABRA2GABRB2ALDH1A1LMNA | |
| SCHEMBL7012691 | 0.85 | EPHA2 (0.45) | PIM1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL7009999 | 0.84 | STAT3 (0.48) | NPC1ALDH1A1LMNAMAPTSTAT3 | |
| SCHEMBL21640202 | 0.84 | CYP2C19 (0.42) | NPC1GABRA2GABRB2PIM1IRAK1 | |
| SCHEMBL10716058 | 0.84 | STAT3 (0.44) | NPC1PIM1IRAK1CAMK2BCAMK2G | |
| SCHEMBL7007886 | 0.84 | MAPT (0.44) | NPC1GABRA2GABRB2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153580-B2 | NAPHTHYRIDINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4956465-A | Bactericides | BAYER AKTIENGESELLSCHAFT (DE) | 1990-09-11 | — | — | US | disclosed |
| EP-0153580-B1 | NAPHTHYRIDINE ANTIBACTERIAL COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-01-25 | — | — | EP | disclosed |
| EP-0153580-A1 | Naphthyridine antibacterial compounds | ABBOTT LABORATORIES (US) | 1985-09-04 | — | — | EP | disclosed |