Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 11/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | ATP4A | P20648 | 1/20 | 0.41 |
| ▸ | ATP4B | P51164 | 1/20 | 0.41 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011597 | 0.89 | ATP4A (0.44) | HTR1ADRD2PLA2G1BATP4AATP4B | |
| SCHEMBL7014295 | 0.86 | PLA2G1B (0.49) | ABCB1PLA2G1BATP4AATP4B | |
| SCHEMBL7010964 | 0.84 | PLA2G1B (0.47) | PLA2G1BATP4AATP4B | |
| SCHEMBL8323820 | 0.83 | PLA2G1B (0.51) | PLA2G1BMAOBATP4AATP4BSLC1A5 | |
| SCHEMBL7006186 | 0.83 | PLA2G1B (0.48) | ABCB1HTR1ADRD2PLA2G1BATP4A | |
| SCHEMBL7005845 | 0.82 | ABCB1 (0.47) | ABCB1HTR1ADRD2PLA2G1BMAOB | |
| SCHEMBL7010500 | 0.80 | PLA2G1B (0.55) | PLA2G1B | |
| SCHEMBL7014264 | 0.78 | PLA2G1B (0.42) | ABCB1HTR1ADRD2PLA2G1BBCHE | |
| SCHEMBL8321751 | 0.77 | L3MBTL1 (0.46) | PLA2G1BATP4AATP4B | |
| SCHEMBL8012905 | 0.77 | PLA2G1B (0.60) | PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| CN-1158121-A | Indolizine sPLA2Inhibitors | LILLY CO ELI (US) | 1997-08-27 | — | — | CN | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |