Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | VNN1 | O95497 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | ATP4A | P20648 | 1/20 | 0.43 |
| ▸ | ATP4B | P51164 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014844 | 0.90 | ATM (0.48) | MRGPRX4SRD5A2MAOBMAPTALDH1A1 | |
| SCHEMBL7011444 | 0.86 | ATP4A (0.43) | MRGPRX4SRD5A2KMT2AATMPLA2G1B | |
| SCHEMBL9080274 | 0.84 | PLA2G1B (0.45) | MRGPRX4MAOBVNN1PLA2G1BNR4A2 | |
| SCHEMBL7016240 | 0.83 | ATM (0.44) | MRGPRX4ATMPLA2G1BATP4AATP4B | |
| SCHEMBL7013035 | 0.82 | ABCB1 (0.52) | ABCB1HTR1ADRD2MAOBPLA2G1B | |
| SCHEMBL7006665 | 0.81 | PLA2G1B (0.43) | MRGPRX4MAPTKMT2AATMPLA2G1B | |
| SCHEMBL8321751 | 0.79 | L3MBTL1 (0.46) | MRGPRX4MAPTALDH1A1KMT2AATM | |
| SCHEMBL7005971 | 0.79 | MRGPRX4 (0.45) | MRGPRX4MAPTALDH1A1KMT2APLA2G1B | |
| SCHEMBL7013814 | 0.79 | ATP4A (0.42) | MRGPRX4SRD5A2MAPTALDH1A1KMT2A | |
| SCHEMBL7006648 | 0.78 | PLA2G1B (0.44) | MAPTALDH1A1KMT2APLA2G1BATP4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |