SCHEMBL7013091

SCHEMBL7013091

CCOC(=O)Nc1cc([N+](=O)[O-])c(F)cc1F

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.51
SMN1; SMN2 Q16637 5/20 0.50
HPGD P15428 3/20 0.50
LMNA P02545 3/20 0.50
POLB P06746 2/20 0.50
GALR2 O43603 1/20 0.50
MITF O75030 1/20 0.50
HSP90AA1 P07900 1/20 0.50
XBP1 P17861 1/20 0.50
CCR6 P51684 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
KMT2A Q03164 1/20 0.45
MAPT P10636 5/20 0.43
PKM P14618 2/20 0.43
RECQL P46063 2/20 0.42
NPC1 O15118 1/20 0.41
CRHBP P24387 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8700206 0.94 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2HPGDLMNAPOLB
SCHEMBL9843482 0.83 ALDH1A1 (0.43) ALDH1A1SMN1; SMN2HPGDLMNAPOLB
SCHEMBL7009210 0.81 NPC1 (0.50) ALDH1A1SMN1; SMN2LMNAPOLBMITF
SCHEMBL7008553 0.81 CYP17A1 (0.44) ALDH1A1SMN1; SMN2HPGDLMNAPOLB
SCHEMBL16515814 0.81 LMNA (0.47) ALDH1A1SMN1; SMN2HPGDLMNAPOLB
SCHEMBL16515812 0.81 LMNA (0.47) ALDH1A1SMN1; SMN2HPGDLMNAPOLB
SCHEMBL8700093 0.80 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2HPGDLMNAPOLB
SCHEMBL8695291 0.80 HCAR3 (0.47) ALDH1A1SMN1; SMN2HPGDLMNAPOLB
SCHEMBL7576322 0.80 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2LMNANPSR1CYP1A2
SCHEMBL9123407 0.80 ALDH1A1 (0.64) ALDH1A1SMN1; SMN2LMNAPOLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787720-B1 PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KK (JP) 2003-07-16 EP disclosed
US-5994575-A Phenylenediamines and process for preparing the same WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
US-5910498-A NOVEL COMPOUNDS HAVING REDUCED CYTOTOXICITY, PHOTOTOXICITY; TREATING BACTERIAL AND VIRAL INFECTIONS WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1999-06-08 US disclosed
EP-0897909-A1 NOVEL PHENYLENEDIAMINES AND PROCESS FOR PREPARING THE SAME WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) 1999-02-24 EP disclosed
EP-0787720-A1 NOVEL PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1997-08-06 EP disclosed